Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

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  • 作者：Hu Fanlei, Jiang Xiang, Guo Chunqing, Li Yingni, Chen Shixian, Zhang Wei, Du Yan, Wang Ping, Zheng Xi, Fang Xiangyu, Li Xin, Song Jing, Xie Yang, Huang Fei, Xue Jimeng, Bai Mingxin, Jia Yuan, Liu Xu, Ren Limin, Zhang Xiaoying, Guo Jianping, Pan Hudan, Su Yin, Yi Huanfa, Ye Hua, Zuo Daming, Li Juan, Wu Huaxiang, Wang Yongfu, Li Ru, Liu Liang, Wang Xiang-Yang, Li Zhanguo
  • 期刊：Nature Communications
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Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.

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