The synergistic anti-tumor effect of schisandrin B and apatinib

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  • 作者:Ya-Jing Li, Hong-Tao Liu, Chao-Jun Xue, Xiao-Qin Xing, Song-Tao Dong, Lin-Shan Wang, Cong-Yang Ding, Lu Meng, Zhan-Jun Dong
  • 期刊:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and transwell invasion assay. Flow cytometry results showed that Sch.B enhanced apoptosis induced by apatinib. The results were confirmed by western blot analysis of the proteins MMP-9, and Bax caspase-9, and -12. These results suggest that combining apatinib and Sch.B is an effective therapeutic strategy for preventing GC progression. [Formula: see text].

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