BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause

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  • 作者：Guo Jun-qi, Gao Xia, Lin Zhi-jie, Wu Wei-zhen, Huang Liang-hu, Dong Hui-yue, Chen Jin, Lu Jun, Fu Yun-fen, Wang Jin, Ma Yu-jie, Chen Xiao-wen, Wu Zhi-xian, He Fu-qiang, Yang Shun-liang, Liao Lian-ming, Zheng Feng, Tan Jian-ming
  • 期刊：BMC CELL BIOLOGY
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Background:The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.

Results:Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced upon co-culture with BMSCs to 4.84%. Cisplatin treatment increased p21 and bax and decreased c-myc mRNA expression, which was reversed upon co-culture with BMSCs. As compared to young rats, increased apoptosis was observed in the perimenopausal rats (P < 0.001). After 3 months, the apoptosis rate in the BMSC group was significantly lower than that of the control group (P = 0.007).

Conclusions:BMSC therapy may protect against GC apoptosis induced by cisplatin and perimenopause. Further studies are necessary to evaluate therapeutic efficacy of BMSCs.

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