Ovalbumin (OVA)-induced intestinal injury is a recurrent and potentially fatal condition. Previous studies have highlighted the roles of exopolysaccharides, particularly a mannose-rich (89.59?%) exopolysaccharide-1 (EPS-1) with a molecular weight of 39.9?kDa, isolated from Bifidobacterium breve H4–2, in repairing intestinal barriers and regulating immune responses. In this study, a mouse model of OVA-induced intestinal injury was used to investigate the effects of EPS-1 on intestinal barrier restoration. The results demonstrated that EPS-1 treatment (400?mg/kg. d) significantly reduced the allergic index (3.25?±?0.43) in OVA-challenged mice ( p ?
A mannose-rich exopolysaccharide-1 isolated from Bifidobacterium breve mitigates ovalbumin-induced intestinal damage in mice by modulation CD4?+?T cell differentiation and inhibiting NF-κB signaling pathway
- 期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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