A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels

Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H 2 S) has been found to have anti-seizure effects. However, its mechanism remains to be explored. In the present study, we showed that a novel H 2 S donor attenuated neuroinflammation by up-regulating ATP-sensitive potassium channel (K ATP ) expression to reduce seizures. The novel H 2 S donor significantly reduced the expression of TNF-α and increased the expression of IL-10 in LPS-treated BV2 cells and the hippocampus of pilocarpine-induced epileptic mice. The modulatory effects of the H 2 S donor on inflammatory cytokines were prevented by glibenclamide, a common K ATP channels blocker. The H 2 S donor promoted the expression of K ATP channel subunits SUR2 and Kir6.1 in LPS-treated BV2 cells and the hippocampus of pilocarpine-induced epileptic mice. In addition, the H 2 S donor reduced the electroencephalography amplitude of hippocampal epileptic waves and reduced seizures in pilocarpine-induced epileptic mice, which were also attenuated by glibenclamide. These results indicated that the novel H 2 S donor reduced seizures and regulated microglial inflammatory cytokines by activating K ATP channels, which may provide a prospective therapeutic strategy for the anti-seizure effects of H 2 S donor.

引用产品已停售或下架